Pharma Focus America

10x Genomics Launches Visium CytAssist Gene and Protein Expression Assay

Thursday, May 25, 2023

10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today the commercial availability of a new Visium CytAssist Gene and Protein Expression product to expand the breadth of the Visium CytAssist spatial analysis capabilities.

"The continued expansion of our Visium platform is a testament to the strength of our innovation engine and demonstrated leadership in spatial biology," said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer. "This launch complements our focus on multiomic analysis and broader protein capabilities on all three of our leading platforms, including single cell and in situ analysis."

Visium CytAssist Gene and Protein Expression enables researchers to simultaneously produce highly multiplexed protein and whole transcriptome RNA data mapped together from the same formalin-fixed, paraffin-embedded (FFPE) tissue section at high spatial resolution. The Human Immune Cell Profiling Panel is an optimized, pre-titrated solution that enables the detection of 31 intracellular and extracellular proteins and includes isotype controls for in-line normalization.

Visium's unique morphology-first workflow allows for H&E staining upstream of chemical treatments made to the tissue section. This allows researchers to study the morphology of their tissue on the same section they also use for deeper spatial multiomic exploration, allowing for three dimensions of spatial analysis on the exact same sample.

"We are excited to leverage the CytAssist Gene and Protein Expression solution to generate more complete assessments of protein, RNA, and morphology together on each and every tissue section," said Dr. David Gate, Assistant Professor of Neurology at Northwestern University. "Spatial transcriptomics with immune cell profiling at the protein level is transforming our understanding of complex biological processes in neurodegenerative disease with great potential to provide new insights into Alzheimer's disease pathology."

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