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Research Insights

The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.

Autoimmunity-associated Allele of Tyrosine Phosphatase Gene PTPN22 Enhances Anti-viral Immunity

Allelic variation in genes that regulate immune cell responses potentially impact an individuals response to self and foreign antigens Genome wide association studies have identified variants in immunerelated genes

An Open-source Facs Automation System for High-throughput Cell Biology

Rapid advances in CRISPRCas and other genome editing technologies are transforming our ability to engineer the properties of cells The ability to deploy these technologies at scale offers unprecedented opportunities for both research and clinical applications

Drug Therapy Problems and Contributing Factors Among Patients With Epilepsy

Antiseizure medications are the mainstay of therapy in the management of epilepsy and are indicated for patients who have experienced two or more unprovoked seizures or a single unprovoked seizure accompanied by additional

Antidiabetic Drug Administration Prevents Bone Mineral Density Loss: Evidence From a Two-sample Mendelian Randomization Study

Osteoporosis is a systemic skeletal condition marked by reduced bone density compromised bone quality and strength resulting in heightened bone fragility and a greater likelihood of fractures

Association of Lipid-lowering Drugs With Osteoarthritis Outcomes From a Drug-target Mendelian Randomization Study

Osteoarthritis is a complex joint disorder with multifactorial etiology characterized by the manifestation of joint pain restricted joint mobility and the potential for functional impairment The pathogenesis of OA is characterized by synovitis

SP3-induced Timeless Transcription Contributes to Cell Growth of Lung Adenocarcinoma Cells

As a common pathological type of nonsmall cell lung cancer lung adenocarcinoma is mostly located in the bronchial mucosal epithelium Typical symptoms of the disease are hemoptysis cough and shortness of breath

Mitoxantrone and abacavir: An ALK protein-targeted in silico proposal for the treatment of non-small cell lung cancer

Lung cancer is one of the major causes of cancer death worldwide and the most frequent cancer in men Although in the last decades there has been considerable research to understand its biological and clinical aspects the overall survival remains poor

Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1

The recent COVID pandemic caused by the severe acute respiratory syndrome coronavirus further intensified the study of hostpathogen interactions and the mechanisms through which viruses suppress cellular antiviral responses

Impact of COVID-19 on Patterns of Drug Utilization: A Case Study at National Hospital

The Coronavirus disease of COVID pandemic and the corresponding mitigation measures have had a discernible impact on drug utilization among outpatients

Exploring the Resistance Mechanism of Triple-negative Breast Cancer to Paclitaxel Through the scRNA-seq Analysis

The triple negative breast cancer is the most malignant subtype of breast cancer with high aggressiveness Although paclitaxelbased chemotherapy scenario present the mainstay in TNBC treatment

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