Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Disproportionality analysis of drug-associated progressive multifocal leukoencephalopathy using spontaneous reports: A 20-year signal detection study based on the FAERS database
Progressive multifocal leukoencephalopathy PML is a rare often fatal demyelinating disease caused by JC virus reactivation in immunocompromised patients With the increasing use of immunosuppressants and biologics
An interpretable machine learning framework for adverse drug reaction prediction from drug-target interactions
Adverse drug reactions ADRs present challenges to patient safety and healthcare systems Current pharmacovigilance methods such as the Yellow Card Scheme YCS provide valuable postmarketing data
Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population
Quantifying cell morphology is central to understanding cellular regulation fate and heterogeneity yet conventional imagebased analyses often struggle with diverse or irregular shapes
High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification
DiversityGenerating Retroelements DGRs are specialized genetic systems typically harnessed in nature to evolve new molecular recognition This mechanism known as mutagenic retrohoming
Structural analysis of antigenic variation and adaptive evolution of the H5N1 neuraminidase gene
The concern regarding HN outbreak particularly the accelerated mutagenesis of its core genomic elements underscores the persistent threat of influenza to global health Neuraminidase NA a pivotal sialidase
Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus
Gene amplification is thought to be common in bacterial populations providing a rapid and reversible mode of adaptation to diverse stresses including the acquisition of antibiotic resistance
Local mitochondrial physiology defined by mtDNA quality guides purifying selection
The mitochondrial genome mtDNA encodes essential subunits of the electron transport chain and ATP synthase Mutations in these genes impair oxidative phosphorylation
Gaussian process emulation for exploring complex infectious disease models
Epidemiological models that aim for a high degree of biological realism by simulating every individual in a population are unavoidably complex with many free parameters which makes systematic explorations of their dynamics
An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms
Microbes of nearly every species can form biofilms communities of cells bound together by a selfproduced matrix It is not understood how variation at the cellular level impacts putatively beneficial colonylevel behaviors
A meta-contrastive learning approach for clinical drug-drug interaction extraction from biomedical literature
Drugdrug interactions DDIs are a significant source of adverse drug events and pose critical challenges to patient safety and clinical decisionmaking Extracting DDIs from biomedical literature plays an essential role in pharmacovigilance
