Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Dipteran flight diversity is shaped by aerodynamic constraints, scaling, and evolutionary trade-offs
Flight has been a key innovation in insect evolution yet the selective and mechanistic pressures shaping their flight motor systems remain poorly understood Here we present a comprehensive comparative analysis of flight in Diptera true flies integrating morphology wingbeat kinematics
The subthalamic nucleus-ventral pallidum projection targeting cholinergic circuits modulates chronic pain
The cholinergic system shows promise for pain management Although cholinergic neurons in the ventral pallidum VP are involved in neuropathic pain the anatomical organization and pharmacology of the cholinergic circuit contributing to the processing of acute and chronic pain remain unknown
Drug Costs in Federally Sponsored Cancer Clinical Trials
Importance Federally sponsored cancer clinical trials FSCCTs address research questions often overlooked by industry eg pharmaceutical or biotechnology companies such as treatment combinations
Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD
Circadian rhythm disruption is increasingly recognized as a contributor to chronic inflammatory disorders however its specific significance and underlying mechanisms in chronic obstructive pulmonary disease
Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells
There is an urgent need to develop a more efficacious antituberculosis vaccine as the current liveattenuated vaccine strain BCG fails to prevent pulmonary infection in adults In this study we leverage a synthetic
Neuromuscular Ultrasound as a Biomarker in the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
A progression marker that indicates early diseaserelated changes and treatment responses in the to date incurable neurodegenerative disease amyotrophic lateral sclerosis ALS is highly desirable
Thymidylate synthase inhibitory drugs induce p53-dependent pathways differently
Thymidylate synthase TS is a key enzyme in thymidylate biosynthesis and an established target of chemotherapeutics such as fluorodeoxyuridine FdUR and raltitrexed RTX Inhibition of TS disrupts
Isoginkgetin increases the expression of metal responsive transcripts but inhibits their translation
Isoginkgetin IGG is a natural bioflavonoid isolated initially from leaf extracts of Gingko biloba trees used in traditional Chinese medicine We previously reported that IGG strongly inhibits nascent protein synthesis
Functional comparison of SP6 RNA polymerase and T7 RNA polymerase
RNAbased therapeutics have emerged as a powerful class of drugs highlighted by the rapid development and success of COVID vaccines Therapeutic RNA synthesis relies on in vitro transcription IVT
Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro
Iscalimab is a nondepleting antiCD monoclonal antibody expected to suppress immune responses by blocking the costimulation by antigenpresenting cells through CDCDL ligation
