Advancing Drug Discovery: Integrating 3D Spheroid Models and Live-Cell Analysis for Compound Screening

Phenotypic screening, which measures defined changes in cellular phenotype in response to a multitude of compounds, is essential in early-stage drug discovery.

The study investigates the use of a 3D single spheroid model combined with live-cell analysis for drug screening. A library of 880 FDA-approved drugs was profiled to assess changes in spheroid size and viability.

Overall, the integration of 3D cellular assays with live-cell analysis offers a powerful and robust tool for phenotypic screening, enhancing drug discovery efforts and ultimately contributing to the development of more effective treatments.