Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery
Raneem Mansoor, Kashif Barkat, Irfan Anjum, Muhammad Aamir, Syed Faisal Badshah, Riaz Ullah, Zafar Iqbal, Muhammad Ahmer Raza
Abstract
Free radical polymerization technique was used to formulate Poloxamer-188 based hydrogels for controlled delivery. A total of seven formulations were formulated with varying concentrations of polymer, monomer ad cross linker. In order to assess the structural properties of the formulated hydrogels, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were carried out.
Introduction
The significance of developing a regulated drug delivery system has greatly increased in contemporary pharmaceutical research [1]. Controlled drug delivery systems (CDDS) offer several advantages, including decreased dose frequency, protection of drugs from degradation, minimal side effects, targeted drug administration, release controlled by stimuli, and improved patient compliance through more effective therapy [2–4]. The use of polymeric three-dimensional networks has gained significant importance in recent years as a viable technology for controlled drug delivery in innovative drug carriers [5].
Materials and method
Ingredients
Ingredients of analytical grade employed in the fabrication of Timolol Maleate-Loaded Poloxamer- co-Poly(acrylic acid) Based Hydrogels were Timolol Maleate (Pharmacsol, Pakistan), Pluronic F127 (Sigma Aldrich, Germany), Acrylic acid (Sigma Aldrich, Germany), Ammonium persulphate (Merck LGea, Germany), Sodium hydroxide (Merck LGea, Germany), Potassium-dihyrogen-phosphate (Merck, Germany), Potassium chloride (Merck, Germany), Phosphoric acid (Merck, Germany), Acetone (Merck, Germany), Hydrochloric acid (Merck, Germany), Methylene bisacrylamide (Sigma Aldrich, UK), Ethanol (Sigma Aldrichco, Germany) and distilled water (Central Lab, University of Lahore).
Results and discussion
FTIR analysis
FTIR spectra of unloaded TiM, drug loaded TiM-GEL 1 hydrogels (optimized formulation) and model drug (TiM) were observed. All hydrogel samples were examined in the range of 4000cm-1 – 600cm-1. FTIR Spectrum for acrylic acid shows the presence of OH groups at the peak of wave number 2987,92 cm−1, whereas peaks at wave number 1694,07 cm-1 and 1634,46 cm-1 indicates C = O and C = C groups, respectively [33].
Conclusion
Hydrogels that are sensitive to changes in pH were created using Pluronic F127 by the use of a free radical polymerization process. The cross-linked hydrogels that were created demonstrated various favorable attributes as a drug delivery system that is both pH dependent and regulated. The fabricated hydrogels exhibited a distinct swelling response that was influenced by the pH of the dissolution media (either pH -1.2 or 7.4) and water absorption.
Citation: Mansoor R, Barkat K, Anjum I, Aamir M, Badshah SF, Ullah R, et al. (2024) Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery. PLoS ONE 19(12): e0309101. https://doi.org/10.1371/journal.pone.0309101
Editor: Muhammad Muzamil Khan, Brigham and Women’s Hospital, UNITED STATES OF AMERICA
Received: April 28, 2024; Accepted: August 5, 2024; Published: December 20, 2024
Copyright: © 2024 Mansoor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All the findings related to data are present within the manuscript.
Funding: The authors wish to thank Researchers Supporting Project Number (RSPD2024R706) at King Saud University Riyadh Saudi Arabia for financial support. (The Project PI is Z.I).
Competing interests: The authors have declared that no competing interests exist.
