Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Neuromuscular Ultrasound as a Biomarker in the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
A progression marker that indicates early diseaserelated changes and treatment responses in the to date incurable neurodegenerative disease amyotrophic lateral sclerosis ALS is highly desirable
Thymidylate synthase inhibitory drugs induce p53-dependent pathways differently
Thymidylate synthase TS is a key enzyme in thymidylate biosynthesis and an established target of chemotherapeutics such as fluorodeoxyuridine FdUR and raltitrexed RTX Inhibition of TS disrupts
Isoginkgetin increases the expression of metal responsive transcripts but inhibits their translation
Isoginkgetin IGG is a natural bioflavonoid isolated initially from leaf extracts of Gingko biloba trees used in traditional Chinese medicine We previously reported that IGG strongly inhibits nascent protein synthesis
Functional comparison of SP6 RNA polymerase and T7 RNA polymerase
RNAbased therapeutics have emerged as a powerful class of drugs highlighted by the rapid development and success of COVID vaccines Therapeutic RNA synthesis relies on in vitro transcription IVT
Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro
Iscalimab is a nondepleting antiCD monoclonal antibody expected to suppress immune responses by blocking the costimulation by antigenpresenting cells through CDCDL ligation
Barrier-to-autointegration factor protects against the cGAS-STING response to chromatin bridges
Cellular damage or stress can lead to disorganization mislocalization or damage to selfDNA that can activate intracellular innate immune response mechanisms Micronuclei such as can occur following mitotic defects
A simple model captures key characteristics of biological non-deterministic genotype-phenotype maps
By connecting genotypic mutations to the higherlevel phenotypes relevant for selection genotypephenotype GP maps play a key role in evolution GP maps are typically investigated using computational models
Uncovering the mechanisms of synergistic drug combinations in non-small cell lung cancer through metagene-based classification
Drug resistance remains a significant challenge in treating nonsmall cell lung cancer NSCLC Identifying synergistic
Measurement properties of the 30-second sit-to-stand test in post COVID-19 condition: Results from the PYCNOVID randomised controlled trial
The second sittostand test sSTS is a frequently used measure of functional capacity in postCOVID condition PCC but its measurement properties have not been comprehensively investigated
Methods for analytical validation of novel digital clinical measures: A simulation study
Analytical validation is a crucial step in the evaluation of algorithms that process data from sensorbased digital health technologies sDHTs Analytical validation of novel digital measures can be complicated when reference
