Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations
De novo mutations in the RNA binding protein DDXX cause neurodevelopmental disorders including DDXX syndrome and autism spectrum disorder Amongst mutations identified to date half are missense While DDXX loss of function is known to impair neural cell fate how the landscape of missense mutations impacts neurodevelopment
Drug-Drug interactions prediction calculations between cardiovascular drugs and antidepressants for discovering the potential co-medication risks
Predicting DrugDrug Interactions DDIs enables cost reduction and time savings in the drug discovery process while effectively screening and optimizing drugs The intensification of societal aging and the increase in life stress have led to a growing number of patients suffering from both heart disease and depression These patients often need to use...
Virtual screening and molecular dynamics simulations identify repurposed drugs as potent inhibitors of Histone deacetylase 1: Implication in cancer therapeutics
Epigenetic processes are the critical events in carcinogenesis Histone modification plays a crucial role in gene expression regulation where histone deacetylases HDACs are key players in epigenetic processes Inhibiting HDACs has shown promise in modern cancer therapy
In silico drug repurposing at the cytoplasmic surface of human aquaporin 1
Aquaporin AQP is a key channel for water transport in peritoneal dialysis Inhibition of AQP could therefore impair water transport during peritoneal dialysis It is not known whether inhibition of AQP occurs unintentionally due to offtarget interactions of administered medications
Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches
The major problem in cases of chronic hepatitis B CHB is the failure of the patients immune response to eliminate the covalently closed circular DNA cccDNA minichromosome of hepatitis B virus HBV Epigenetic regulation involving the HBV core protein HBc and HBV X protein HBx influences the transcription and stability of the cccDNA minichromosome The...
Designing of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation
Human papillomavirus and human papillomavirus have been associated with different lifethreatening cancers including cervical lung penal vulval vaginal anal and oropharyngeal cancers while cervical cancer is the most prominent one Several research studies have suggested that the oncoproteins E and E are the leading cause of cancers associated with...
Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery
Free radical polymerization technique was used to formulate Poloxamer based hydrogels for controlled delivery A total of seven formulations were formulated with varying concentrations of polymer monomer ad cross linker In order to assess the structural properties of the formulated hydrogels Fourier Transform Infrared Spectroscopy FTIR Thermogravime...
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
Autism spectrum disorder ASD is a neurodevelopmental disorder characterized by deficits in social communication and social interaction and restricted repetitive patterns of behavior interests or activities Given the lack of specific pharmacological therapy for ASD and the clinical heterogeneity of the disorder current biomarker research efforts are...
Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery
Free radical polymerization technique was used to formulate Poloxamer based hydrogels for controlled delivery A total of seven formulations were formulated with varying concentrations of polymer monomer ad cross linker In order to assess the structural properties of the formulated hydrogels Fourier Transform Infrared Spectroscopy FTIR Thermogravime...
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
Autism spectrum disorder ASD is a neurodevelopmental disorder characterized by deficits in social communication and social interaction and restricted repetitive patterns of behavior interests or activities Given the lack of specific pharmacological therapy for ASD and the clinical heterogeneity of the disorder current biomarker research efforts are...
