Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Significant roles in RNA-binding for the amino-terminal regions of Drosophila Pumilio and Nanos
The Drosophila Pumilio Pum and Nanos Nos RNAbinding proteins govern abdominal segmentation in the early embryo as well as a variety of other events during development They bind together to a compound Nanos Response Element NRE
Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer’s disease
Genomewide association studies GWAS performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimers disease AD
Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer’s disease
Genomewide association studies GWAS performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimers disease AD
Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes
Genetic variation can modulate response to treatment GT or environmental stimuli GE both of which can be highly consequential in biomedicine An effective approach to identifying GT signals and gaining insight into molecular
Parental germline mosaicism in genome-wide phased de novo variants: Recurrence risk assessment and implications for precision genetic counselling
De novo mutations DNMs have a significant impact on human health notably through their contribution to developmental disorders DNMs occur in both paternal and maternal germlines via diverse mechanisms
Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector
Parasites can counteract host immunity by suppressing nucleotide binding and leucinerich repeat NLR proteins that function as immune receptors We previously showed that a cyst nematode virulence effector SPRYSEC SS binds and inhibits oligomerisation
TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1–1 in human hepatocellular carcinoma cells
Recent studies expanded our knowledge of diverse prosurvival functions of short noncoding vault RNAs One of the human vault RNA paralogs vtRNA modulates several intracellular processes including proliferation apoptosis autophagy and drug resistance in various types of human cancer cells
Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches
Lung cancer is one of the most common cancer and the leading cause of cancerrelated death worldwide Early detection of lung cancer can help reduce the death rate therefore the identification of potential biomarkers is crucial
mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis
RNA abundance is controlled by rates of synthesis and degradation Although misregulation of RNA turnover is linked to neurodevelopmental disorders how it contributes to cortical development is largely unknown
Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa
The RNA degradosome is a bacterial multiprotein complex mediating mRNA processing and degradation In Pseudomonadota this complex assembles on the Cterminal domain CTD of RNase E through short linear motifs SLiMs that determine
