Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Eps epidermal growth factor receptor pathway substrate homology domaincontaining proteins EHDs comprise a family of eukaryotic dynaminrelated ATPases that participate in various endocytic membrane trafficking pathways Dysregulation of EHDs function has been implicated in various diseases including cancer
APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing
Disrupted alternative splicing plays a determinative role in neurological diseases either as a direct cause or as a driver in disease susceptibility Transcriptomic profiling of aged human postmortem brain samples has uncovered hundreds of aberrant mRNA splicing events in Alzheimers disease AD brains associating dysregulated RNA splicing with diseas...
Quantitative Proteomics Analysis Reveals Possible Anticancer Mechanisms of 5’-deoxy-5’-methylthioadenosine in Cholangiocarcinoma Cells
Cholangiocarcinoma is an aggressive cancer originating from bile duct epithelium particularly prevalent in Asian countries with liver fluke infections Current chemotherapy for CCA often fails due to drug resistance
Identification of Circulating miRNAs as Fracture-related Biomarkers
Fracture nonunions affect many patients leading to functional and psychosocial disability Several risk factors have been described and include biological
A Novel Immunofluorescent Test System for SARS-CoV-2 Detection in Infected Cells
COVID is an acute respiratory infection caused by the coronavirus SARSCoV characterized by high contagiousness and mortality of the infected population which determines its high socioeconomic significance
Cellular pharmacokinetic of methotrexate and its modulation by folylpolyglutamate synthetase and γ-glutamyl hydrolase in tumor cells
Methotrexate is a folic acid analog with broadspectrum antineoplastic activity which is used in the treatment of various solid tumors
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights
Singlecell sequencing has the ability to inspect the cellular heterogeneity of tissue and cancer with unprecedented details and as such provides important insights into the cellular origin and cellspecific molecular defects
A Role for the C. Elegans Argonaute Protein CSR-1 in Small Nuclear RNA 3’ Processing
Eukaryotic RNA splicing is catalyzed by the spliceosome that removes noncoding intron segments from premRNA transcripts to produce a mature mRNA for protein translation A core component of the spliceosome is the uridylaterich small nuclear RNA
Deciphering Molecular Bridges: Unveiling the Interplay Between Metabolic Syndrome and Alzheimer’s Disease Through a Systems Biology Approach and Drug Repurposing
Alzheimers disease is a progressive neurodegenerative disorder defined by amyloid plaques and neurofibrillary tangles accumulation AD progresses from the hippocampus through the frontal and other brain regions
Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking
In recent years our understanding of the RNAbinding protein interactome has become significantly more informed The development of methods such as RNAinteractome capture
