Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Integration of pharmacophore-based virtual screening, molecular docking, ADMET analysis, and MD simulation for targeting EGFR: A comprehensive drug discovery study using commercial databases
The epidermal growth factor receptor EGFR a crucial component of cellular signaling pathways is frequently dysregulated in a range of cancers EGFR targeting has become a viable approach in the development of anticancer medications This study employs an integrated approach to drug discovery combining multiple computational methodologies to identify...
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery
Osteoarthritis OA is the most common form of arthritis and a leading cause of pain and disability in adults A central feature is progressive cartilage degradation and matrix fragment formation driven by the excessive production of matrix metalloproteinases MMPs such as MMP by articular chondrocytes I
Morphine self-administration is inhibited by the antioxidant N‐acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration
The treatment of opioid addiction mainly involves the medical administration of methadone or other opioids aimed at gradually reducing dependence and consequently the need for illicit opioid procurement Thus initiating opioid maintenance therapy with a lower level of dependence would be advantageous
Small extracellular vesicles from the human endothelial cell line EA.hy 926 exert a self-cell activation and modulate DENV-2 genome replication and infection in naïve endothelial cells
Extracellular vesicles EVs play crucial roles in cell signaling and communication transporting molecules that convey a message to target cells
Drug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction
Heart failure HF with reduced ejection fraction HFrEF is a risk factor for druginduced QT interval prolongation It is unknown if HF with preserved ejection fraction HFpEF is also associated with an increased risk Dofetilide and sotalol are potent QT
Expanding the repertoire of Antibody Drug Conjugate (ADC) targets with improved tumor selectivity and range of potent payloads through in-silico analysis
AntibodyDrug Conjugates ADCs have emerged as a promising class of targeted cancer therapeutics Further refinements are essential to unlock their full potential which is currently limited by a lack of validated targets and payloads
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Eps epidermal growth factor receptor pathway substrate homology domaincontaining proteins EHDs comprise a family of eukaryotic dynaminrelated ATPases that participate in various endocytic membrane trafficking pathways Dysregulation of EHDs function has been implicated in various diseases including cancer
APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing
Disrupted alternative splicing plays a determinative role in neurological diseases either as a direct cause or as a driver in disease susceptibility Transcriptomic profiling of aged human postmortem brain samples has uncovered hundreds of aberrant mRNA splicing events in Alzheimers disease AD brains associating dysregulated RNA splicing with diseas...
Quantitative Proteomics Analysis Reveals Possible Anticancer Mechanisms of 5’-deoxy-5’-methylthioadenosine in Cholangiocarcinoma Cells
Cholangiocarcinoma is an aggressive cancer originating from bile duct epithelium particularly prevalent in Asian countries with liver fluke infections Current chemotherapy for CCA often fails due to drug resistance
Identification of Circulating miRNAs as Fracture-related Biomarkers
Fracture nonunions affect many patients leading to functional and psychosocial disability Several risk factors have been described and include biological
