Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Cellular pharmacokinetic of methotrexate and its modulation by folylpolyglutamate synthetase and γ-glutamyl hydrolase in tumor cells
Methotrexate is a folic acid analog with broadspectrum antineoplastic activity which is used in the treatment of various solid tumors
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights
Singlecell sequencing has the ability to inspect the cellular heterogeneity of tissue and cancer with unprecedented details and as such provides important insights into the cellular origin and cellspecific molecular defects
A Role for the C. Elegans Argonaute Protein CSR-1 in Small Nuclear RNA 3’ Processing
Eukaryotic RNA splicing is catalyzed by the spliceosome that removes noncoding intron segments from premRNA transcripts to produce a mature mRNA for protein translation A core component of the spliceosome is the uridylaterich small nuclear RNA
Deciphering Molecular Bridges: Unveiling the Interplay Between Metabolic Syndrome and Alzheimer’s Disease Through a Systems Biology Approach and Drug Repurposing
Alzheimers disease is a progressive neurodegenerative disorder defined by amyloid plaques and neurofibrillary tangles accumulation AD progresses from the hippocampus through the frontal and other brain regions
Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking
In recent years our understanding of the RNAbinding protein interactome has become significantly more informed The development of methods such as RNAinteractome capture
Zmiz1 is a Novel Regulator of Lymphatic Endothelial Cell Gene Expression and Function
Lymphatic vasculature plays a crucial role in maintaining tissue fluid homeostasis facilitating lipid absorption and conducting immune surveillance The proper establishment of a functional lymphatic system is vital for embryonic
Covar: A Generalizable Machine Learning Approach to Identify the Coordinated Regulators Driving Variational Gene Expression
The advent of highthroughput genomic data acquisition techniques has generated immense interest in the statistical and datadriven analysis of biological and biochemical interactions One such approach is network inference
A Simulation-based Comparison of Drug-drug Interaction Signal Detection Methods
Polypharmacy the use of multiple medicines has increased as the average life expectancy and the prevalence of multimorbidity has increased Adverse events caused by the administration of many drugs
A Quantitative Genetic Model of Background Selection in Humans
The continual influx of new mutations into populations is the ultimate source of all adaptations but the vast majority of mutations either do not affect fitness or are deleterious Natural selection works to eliminate these deleterious
Olaparib Not Cost-effective as Maintenance Therapy for Platinum-sensitive, BRCA1/2 Germline-mutated Metastatic Pancreatic Cancer
To assess the costeffectiveness and budget impact of olaparib as a maintenance therapy in platinumresponsive metastatic pancreatic cancer patients harboring a germline BRCA mutation
