Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Development of a SARS-CoV-2 Nucleocapsid-CD154 Chimeric Antigen in HEK-293 Cells for COVID-19 Vaccine
Despite that more than one hundred vaccines against SARSCoV have been developed and that some of them were evaluated in clinical trials the latest results revealed that these vaccines still face great challenges Among the components of the virus
Coarse-grained Molecular Dynamics-guided Immunoinformatics to Explain the Binder and Non-binder Classification of Cytotoxic T-cell Epitope for Sars-cov-2 Peptide-based Vaccine Discovery
The increasing variants of SARSCoV viruses raised concerns about the vaccines effectiveness which currently is based on the wholeinactivated virus mRNA adenovirus viral vector and recombinant protein
Application of a Life Table Approach to Assess Duration of BNT162b2 Vaccine-derived Immunity by Age Using COVID-19 Case Surveillance Data During the Omicron Variant Period
SARSCoV Omicron variants have the potential to impact vaccine effectiveness and duration of vaccinederived immunity We analyzed US multijurisdictional COVID vaccine breakthrough surveillance data
Development of Multi-drug Resistance to Anticancer Drugs in HepG2 Cells Due to MRP2 Upregulation on Exposure to Menthol
Menthol exerts relaxing antibacterial and antiinflammatory activities and is marketed as a functional food and therapeutic drug
H4k20me3 is Important for Ash1-mediated H3k36me3 and Transcriptional Silencing in Facultative Heterochromatin in a Fungal Pathogen
Chromatin the assembly of DNA RNA and proteins that constitutes chromosomes can assume active and inactive states that are correlated with different histone and DNA modifications Transcriptionally inactive
Adenylosuccinate Lyase Deficiency Affects Neurobehavior via Perturbations to Tyramine Signaling in Caenorhabditis Elegans
Congenital metabolic disorders CMDs arise from genetic mutations that result in reduction or absence of enzymatic activity leading to phenotypic clinical manifestations Although most CMDs are rare individually
Microtubules Oppose Cortical Actomyosin-driven Membrane Ingression During C. Elegans Meiosis I Polar Body Extrusion
During C elegans oocyte meiosis I cytokinesis and polar body extrusion cortical actomyosin is locally remodeled to assemble a contractile ring that forms within and remains part of a much larger and actively contractile cortical actomyosin network
ADAR-mediated Regulation of PQM-1 Expression in Neurons Impacts Gene Expression Throughout C. Elegans and Regulates Survival From Hypoxia
The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive For most organisms the nervous system serves as the master regulator in communicating information
The Transcription Factor DUX4 Orchestrates Translational Reprogramming by Broadly Suppressing Translation Efficiency and Promoting Expression of DUX4-induced mRNAs
Translational control is critical for cell fate transitions during development lineage specification and tumorigenesis Here we show that the transcription factor double homeobox protein DUX and its previously characterized transcriptional program
Safety and Immunogenicity of a New Formulation of a Pentavalent DTwP-HepB Vaccine in Healthy Indian Infants–A Randomized Study
Pentavalent vaccines DTPHepBHib have been introduced in many countries in their routine public immunization programmes to protect against diphtheria D tetanus T pertussis P hepatitis B Hep B and Hemophilus influenzae type b Hib diseases
