Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Mapping Genetic Effects on Cell Type-specific Chromatin Accessibility and Annotating Complex Immune Trait Variants Using Single Nucleus ATAC-seq in Peripheral Blood
Gene regulation is highly cell typespecific and understanding the function of noncoding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution
Mutators Can Drive the Evolution of Multi-resistance to Antibiotics
Antibiotic combination therapies are an approach used to counter the evolution of resistance their purported benefit is they can stop the successive emergence of independent resistance mutations
Risk of myocarditis and Pericarditis After a COVID-19 mRNA Vaccine Booster and After COVID-19 in Those With and Without Prior SARS-COV-2 Infection
An increased risk of myocarditis or pericarditis after priming with mRNA Coronavirus Disease COVID vaccines has been shown but information on the risk postbooster is limited
A polycistronic transgene design for combinatorial genetic perturbations from a single transcript in Drosophila
Experimental models that capture the genetic complexity of human disease and allow mechanistic explorations of the underlying cell tissue and organ interactions are crucial to furthering our understanding of disease biology
Structure Learning for Gene Regulatory Networks
Inference of biological network structures is often performed on highdimensional data yet is hindered by the limited sample size of high throughput omics data typically available
Pbp1 Associates With Puf3 and Promotes Translation of Its Target mRNAs Involved in Mitochondrial Biogenesis
Pbp polyAbinding proteinbinding protein is a cytoplasmic stress granule marker that is capable of forming condensates that function in the negative regulation of TORC signaling under respiratory conditions
TORC1 Regulation of Dendrite Regrowth After Pruning is Linked to Actin and Exocytosis
Neurite pruning and regrowth are important mechanisms to adapt neural circuits to distinct developmental stages
Integration of a Multi-omics Stem Cell Differentiation Dataset Using a Dynamical Model
Stem cell differentiation is a highly dynamic process involving pervasive changes in gene expression The large majority of existing studies has characterized differentiation at the level of individual molecular profiles such as the transcriptome or the proteome
CRISPR-Cas Effector Specificity and Cleavage Site Determine Phage Escape Outcomes
CRISPRmediated interference relies on complementarity between a guiding CRISPR RNA crRNA and target nucleic acids to provide defense against bacteriophage
Characterization of GSDME in Amphioxus Provides Insights Into the Functional Evolution of GSDM-mediated Pyroptosis
Members of the gasdermin GSDM family are poreforming effectors that cause membrane permeabilization and pyroptosis a lytic proinflammatory type of cell death
