Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Beyond a PPR-RNA Recognition Code: Many Aspects Matter for the Multi-targeting Properties of RNA Editing Factor PPR56
The mitochondrial CtoU RNA editing factor PPR of the moss Physcomitrium patens is an RNAbinding pentatricopeptide repeat protein equipped with a terminal DYWtype cytidine deaminase domain
Muscleblind-1 Interacts With Tubulin mRNAs to Regulate the Microtubule cytoskeleton in C. elegans Mechanosensory Neurons
A highly ordered functional neuronal circuit comprises polarized nerve cells which are compartmentalized into dendrites and axons for unidirectional reception and transmission of information
Functional Mapping of N-terminal Residues in the Yeast Proteome Uncovers Novel Determinants for Mitochondrial Protein Import
As soon as they emerge from the ribosomal tunnel the protein nascent chains recruit factors that will play key roles in their life cycle Such recruitment is dependent on the nature of the protein Nterminal amino acid residues
Accurate Detection of Shared Genetic Architecture From GWAS Summary Statistics in the Small-sample Context
Genetic pleiotropy is the association of a genetic variant with more than one trait and is a pervasive property of the human genome
Genomic Diversity Landscapes in Outcrossing and Selfing Caenorhabditis Nematodes
Population genomics aims to infer the evolutionary forces and historical processes that have shaped genetic variation within species while considering the effects of a range of factors such as natural selection
Optogenetic Cleavage of the Miro GTPase Reveals the Direct Consequences of Real-time Loss of Function in Drosophila
Miro GTPases control mitochondrial morphology calcium homeostasis and regulate mitochondrial distribution by mediating their attachment to the kinesin and dynein motor complex It is not clear however how Miro proteins spatially and temporally integrate their function as acute disruption of protein function has not been performed
A Flexible Empirical Bayes Approach to Multivariate Multiple Regression, and Its Improved Accuracy in Predicting Multi-tissue Gene Expression From Genotypes
Predicting phenotypes from genotypes is a fundamental task in quantitative genetics With technological advances it is now possible to measure multiple phenotypes in large samples
Two RNA Binding Proteins, ADAD2 and RNF17, Interact to Form a Heterogeneous Population of Novel Meiotic Germ Cell Granules With Developmentally Dependent Organelle Association
Mammalian male germ cell differentiation relies on complex RNA biogenesis events many of which occur in nonmembrane bound organelles termed RNA germ cell granules that are rich in RNA binding proteins RBPs
Parallels and Contrasts Between the Cnidarian and Bilaterian Maternal-to-zygotic Transition Are Revealed in hydractinia embryos
Embryogenesis requires coordinated gene regulatory activities early on that establish the trajectory of subsequent development during a period called the maternaltozygotic transition MZT
The CERV Protein of Cer1, a C. elegans LTR Retrotransposon, is Required for Nuclear Export of Viral Genomic RNA and Can Form Giant Nuclear Rods
Retroviruses and closely related LTR retrotransposons export fulllength unspliced genomic RNA gRNA for packaging into virions and to serve as the mRNA encoding GAG and POL polyproteins
