Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Antimicrobial Drug Resistant Features of Mycobacterium Tuberculosis Associated With Treatment Failure
Tuberculosis stands as a prominent cause of mortality in developing countries The treatment of tuberculosis involves a complex procedure requiring the administration of a panel of at least four antimicrobial drugs for the duration of six months
The Inflammatory Response of Human Pancreatic Cancer Samples Compared to Normal Controls
Pancreatic ductal adenocarcinoma is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options PDAC growth has been linked to alterations
Computational Design of Novel Nanobodies Targeting the Receptor Binding Domain of Variants of Concern of SARS-CoV-2
The emergence of COVID caused by SARSCoV has resulted in a severe global public health emergency The infection process involves the receptor binding motif of the SARSCoV RBD spike protein
Diverse Microtubule-targeted Anticancer Agents Kill Cells by Inducing Chromosome Missegregation on Multipolar Spindles
Microtubule poisons are one of the most commonly used therapies for numerous malignancies including primary and metastatic breast cancers of all subtypes
A Drug Design Strategy Based on Molecular Docking and Molecular Dynamics Simulations Applied to Development of Inhibitor Against Triple-negative Breast Cancer by Scutellarein Derivatives
Breast cancer is a difficult challenge for the global public health community and the diseases growing prevalence It seems to substantially affect the lives of a large number of females globally by breast cancer
Designing Peptides Predicted to Bind to the Omicron Variant Better Than ACE2 via Computational Protein Design and Molecular Dynamics
Brought about by severe acute respiratory syndrome coronavirus coronavirus disease pandemic has resulted in large numbers of worldwide deaths and cases Several SARSCoV variants have evolved and Omicron
Development of a SARS-CoV-2 Nucleocapsid-CD154 Chimeric Antigen in HEK-293 Cells for COVID-19 Vaccine
Despite that more than one hundred vaccines against SARSCoV have been developed and that some of them were evaluated in clinical trials the latest results revealed that these vaccines still face great challenges Among the components of the virus
Coarse-grained Molecular Dynamics-guided Immunoinformatics to Explain the Binder and Non-binder Classification of Cytotoxic T-cell Epitope for Sars-cov-2 Peptide-based Vaccine Discovery
The increasing variants of SARSCoV viruses raised concerns about the vaccines effectiveness which currently is based on the wholeinactivated virus mRNA adenovirus viral vector and recombinant protein
Application of a Life Table Approach to Assess Duration of BNT162b2 Vaccine-derived Immunity by Age Using COVID-19 Case Surveillance Data During the Omicron Variant Period
SARSCoV Omicron variants have the potential to impact vaccine effectiveness and duration of vaccinederived immunity We analyzed US multijurisdictional COVID vaccine breakthrough surveillance data
Development of Multi-drug Resistance to Anticancer Drugs in HepG2 Cells Due to MRP2 Upregulation on Exposure to Menthol
Menthol exerts relaxing antibacterial and antiinflammatory activities and is marketed as a functional food and therapeutic drug
