Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Optogenetic Cleavage of the Miro GTPase Reveals the Direct Consequences of Real-time Loss of Function in Drosophila
Miro GTPases control mitochondrial morphology calcium homeostasis and regulate mitochondrial distribution by mediating their attachment to the kinesin and dynein motor complex It is not clear however how Miro proteins spatially and temporally integrate their function as acute disruption of protein function has not been performed
A Flexible Empirical Bayes Approach to Multivariate Multiple Regression, and Its Improved Accuracy in Predicting Multi-tissue Gene Expression From Genotypes
Predicting phenotypes from genotypes is a fundamental task in quantitative genetics With technological advances it is now possible to measure multiple phenotypes in large samples
Two RNA Binding Proteins, ADAD2 and RNF17, Interact to Form a Heterogeneous Population of Novel Meiotic Germ Cell Granules With Developmentally Dependent Organelle Association
Mammalian male germ cell differentiation relies on complex RNA biogenesis events many of which occur in nonmembrane bound organelles termed RNA germ cell granules that are rich in RNA binding proteins RBPs
Parallels and Contrasts Between the Cnidarian and Bilaterian Maternal-to-zygotic Transition Are Revealed in hydractinia embryos
Embryogenesis requires coordinated gene regulatory activities early on that establish the trajectory of subsequent development during a period called the maternaltozygotic transition MZT
The CERV Protein of Cer1, a C. elegans LTR Retrotransposon, is Required for Nuclear Export of Viral Genomic RNA and Can Form Giant Nuclear Rods
Retroviruses and closely related LTR retrotransposons export fulllength unspliced genomic RNA gRNA for packaging into virions and to serve as the mRNA encoding GAG and POL polyproteins
A Predictive Molecular Signature Consisting of IncRNAs Associated With Cellular Senescence for the Prognosis of Lung Adenocarcinoma
The role of long noncoding RNAs lncRNAs has been verified by more and more researches in recent years However there are few reports on cellular senescenceassociated lncRNAs in lung adenocarcinoma LUAD
Partial Sequence Identity in a 25-nucleotide Long Element is Sufficient for Transcriptional Adaptation in the caenorhabditis elegans act-5/act-3 Model
Genetic robustness can be achieved via several mechanisms including transcriptional adaptation TA a sequence similaritydriven process whereby mutant mRNA degradation products modulate directly or indirectly
Risk of myocarditis and Pericarditis After a COVID-19 mRNA Vaccine Booster and After COVID-19 in Those With and Without Prior SARS-COV-2 Infection
An increased risk of myocarditis or pericarditis after priming with mRNA Coronavirus Disease COVID vaccines has been shown but information on the risk postbooster is limited With the now high prevalence of prior Severe Acute Respiratory Syndrome Coronavirus SARSCoV infection we assessed the effect of prior infection on the vaccine risk and the ri...
Combinations of Genes at the 16p11.2 and 22q11.2 Cnvs Contribute to Neurobehavioral Traits
The p and q copy number variants CNVs are associated with neurobehavioral traits including autism spectrum disorder ASD schizophrenia bipolar disorder
Mapping Genetic Effects on Cell Type-specific Chromatin Accessibility and Annotating Complex Immune Trait Variants Using Single Nucleus ATAC-seq in Peripheral Blood
Gene regulation is highly cell typespecific and understanding the function of noncoding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution
