Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Many but Not All Deep Neural Network Audio Models Capture Brain Responses and Exhibit Correspondence Between Model Stages and Brain Regions
An overarching aim of neuroscience is to build quantitatively accurate computational models of sensory systems Success entails models that take sensory signals as input and reproduce the behavioral judgments mediated by a sensory system as well as its internal representations
A New Variant of the Colistin Resistance Gene MCR-1 With Co-resistance to Β-lactam Antibiotics Reveals a Potential Novel Antimicrobial Peptide
ColistinPolymyxin is a lastresort antibiotic against infections caused by highly drugresistant bacteria particularly carbapenemresistant Enterobacterales However the emergence of a novel plasmidmediated colistin resistance gene named mcr in threatened the clinical effectiveness of colistin
Potential Drug–drug Interactions of Frequently Prescribed Medications in Long COVID Detected by Two Electronic Databases
The focus of this study was on frequently prescribed medications for patients with both long COVID and other common chronic conditions such as diabetes mellitus hypertension dyslipidemia and chronic infections
Vaccinomics-aided Next-generation Novel Multi-epitope-based Vaccine Engineering Against Multidrug Resistant Shigella Sonnei: Immunoinformatics and Chemoinformatics Approaches
Shigella sonnei is a gramnegative bacterium and is the primary cause of shigellosis in advanced countries An exceptional rise in the prevalence of the disease has been reported in Asia the Middle East and Latin America
Antimicrobial Drug Resistant Features of Mycobacterium Tuberculosis Associated With Treatment Failure
Tuberculosis stands as a prominent cause of mortality in developing countries The treatment of tuberculosis involves a complex procedure requiring the administration of a panel of at least four antimicrobial drugs for the duration of six months
The Inflammatory Response of Human Pancreatic Cancer Samples Compared to Normal Controls
Pancreatic ductal adenocarcinoma is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options PDAC growth has been linked to alterations
Computational Design of Novel Nanobodies Targeting the Receptor Binding Domain of Variants of Concern of SARS-CoV-2
The emergence of COVID caused by SARSCoV has resulted in a severe global public health emergency The infection process involves the receptor binding motif of the SARSCoV RBD spike protein
Diverse Microtubule-targeted Anticancer Agents Kill Cells by Inducing Chromosome Missegregation on Multipolar Spindles
Microtubule poisons are one of the most commonly used therapies for numerous malignancies including primary and metastatic breast cancers of all subtypes
A Drug Design Strategy Based on Molecular Docking and Molecular Dynamics Simulations Applied to Development of Inhibitor Against Triple-negative Breast Cancer by Scutellarein Derivatives
Breast cancer is a difficult challenge for the global public health community and the diseases growing prevalence It seems to substantially affect the lives of a large number of females globally by breast cancer
Designing Peptides Predicted to Bind to the Omicron Variant Better Than ACE2 via Computational Protein Design and Molecular Dynamics
Brought about by severe acute respiratory syndrome coronavirus coronavirus disease pandemic has resulted in large numbers of worldwide deaths and cases Several SARSCoV variants have evolved and Omicron
