Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Antidiabetic Drug Administration Prevents Bone Mineral Density Loss: Evidence From a Two-sample Mendelian Randomization Study
Osteoporosis is a systemic skeletal condition marked by reduced bone density compromised bone quality and strength resulting in heightened bone fragility and a greater likelihood of fractures
Association of Lipid-lowering Drugs With Osteoarthritis Outcomes From a Drug-target Mendelian Randomization Study
Osteoarthritis is a complex joint disorder with multifactorial etiology characterized by the manifestation of joint pain restricted joint mobility and the potential for functional impairment The pathogenesis of OA is characterized by synovitis
SP3-induced Timeless Transcription Contributes to Cell Growth of Lung Adenocarcinoma Cells
As a common pathological type of nonsmall cell lung cancer lung adenocarcinoma is mostly located in the bronchial mucosal epithelium Typical symptoms of the disease are hemoptysis cough and shortness of breath
Mitoxantrone and abacavir: An ALK protein-targeted in silico proposal for the treatment of non-small cell lung cancer
Lung cancer is one of the major causes of cancer death worldwide and the most frequent cancer in men Although in the last decades there has been considerable research to understand its biological and clinical aspects the overall survival remains poor
Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1
The recent COVID pandemic caused by the severe acute respiratory syndrome coronavirus further intensified the study of hostpathogen interactions and the mechanisms through which viruses suppress cellular antiviral responses
Impact of COVID-19 on Patterns of Drug Utilization: A Case Study at National Hospital
The Coronavirus disease of COVID pandemic and the corresponding mitigation measures have had a discernible impact on drug utilization among outpatients
Exploring the Resistance Mechanism of Triple-negative Breast Cancer to Paclitaxel Through the scRNA-seq Analysis
The triple negative breast cancer is the most malignant subtype of breast cancer with high aggressiveness Although paclitaxelbased chemotherapy scenario present the mainstay in TNBC treatment
NeuroD1-GPX4 signaling leads to ferroptosis resistance in hepatocellular carcinoma
Cell death resistance is one of the hallmarks of cancer The balance of cell death plays a vital role in regulating cell population size and tumorigenesis Cell death can be classified as accidental cell death threshold has attracted attention as a potential antitumor therapeutic strategy
Characterization of a Novel Bacteriophage Endolysin (LysAB1245) With Extended Lytic Activity Against Distinct Capsular Types Associated With Acinetobacter Baumannii Resistance
Recently an outbreak of A baumannii infections in coronavirus disease patients has been reported resulting in increased morbidity and mortality rates as well as high treatment costs
Feasibility and Metabolic Outcomes of a Well-formulated Ketogenic Diet as an Adjuvant Therapeutic Intervention for Women With Stage IV Metastatic Breast Cancer
In breast cancer became the most diagnosed cancer worldwidewith an estimated million new casessurpassing lung cancer Early detection and treatment have improved breast cancer survival rates to almost
