Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Designing of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation
Human papillomavirus and human papillomavirus have been associated with different lifethreatening cancers including cervical lung penal vulval vaginal anal and oropharyngeal cancers while cervical cancer is the most prominent one Several research studies have suggested that the oncoproteins E and E are the leading cause of cancers associated with...
Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery
Free radical polymerization technique was used to formulate Poloxamer based hydrogels for controlled delivery A total of seven formulations were formulated with varying concentrations of polymer monomer ad cross linker In order to assess the structural properties of the formulated hydrogels Fourier Transform Infrared Spectroscopy FTIR Thermogravime...
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
Autism spectrum disorder ASD is a neurodevelopmental disorder characterized by deficits in social communication and social interaction and restricted repetitive patterns of behavior interests or activities Given the lack of specific pharmacological therapy for ASD and the clinical heterogeneity of the disorder current biomarker research efforts are...
Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery
Free radical polymerization technique was used to formulate Poloxamer based hydrogels for controlled delivery A total of seven formulations were formulated with varying concentrations of polymer monomer ad cross linker In order to assess the structural properties of the formulated hydrogels Fourier Transform Infrared Spectroscopy FTIR Thermogravime...
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
Autism spectrum disorder ASD is a neurodevelopmental disorder characterized by deficits in social communication and social interaction and restricted repetitive patterns of behavior interests or activities Given the lack of specific pharmacological therapy for ASD and the clinical heterogeneity of the disorder current biomarker research efforts are...
Integration of pharmacophore-based virtual screening, molecular docking, ADMET analysis, and MD simulation for targeting EGFR: A comprehensive drug discovery study using commercial databases
The epidermal growth factor receptor EGFR a crucial component of cellular signaling pathways is frequently dysregulated in a range of cancers EGFR targeting has become a viable approach in the development of anticancer medications This study employs an integrated approach to drug discovery combining multiple computational methodologies to identify...
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery
Osteoarthritis OA is the most common form of arthritis and a leading cause of pain and disability in adults A central feature is progressive cartilage degradation and matrix fragment formation driven by the excessive production of matrix metalloproteinases MMPs such as MMP by articular chondrocytes I
Morphine self-administration is inhibited by the antioxidant N‐acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration
The treatment of opioid addiction mainly involves the medical administration of methadone or other opioids aimed at gradually reducing dependence and consequently the need for illicit opioid procurement Thus initiating opioid maintenance therapy with a lower level of dependence would be advantageous
Small extracellular vesicles from the human endothelial cell line EA.hy 926 exert a self-cell activation and modulate DENV-2 genome replication and infection in naïve endothelial cells
Extracellular vesicles EVs play crucial roles in cell signaling and communication transporting molecules that convey a message to target cells
Drug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction
Heart failure HF with reduced ejection fraction HFrEF is a risk factor for druginduced QT interval prolongation It is unknown if HF with preserved ejection fraction HFpEF is also associated with an increased risk Dofetilide and sotalol are potent QT
