Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector
Parasites can counteract host immunity by suppressing nucleotide binding and leucinerich repeat NLR proteins that function as immune receptors We previously showed that a cyst nematode virulence effector SPRYSEC SS binds and inhibits oligomerisation
TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1–1 in human hepatocellular carcinoma cells
Recent studies expanded our knowledge of diverse prosurvival functions of short noncoding vault RNAs One of the human vault RNA paralogs vtRNA modulates several intracellular processes including proliferation apoptosis autophagy and drug resistance in various types of human cancer cells
Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches
Lung cancer is one of the most common cancer and the leading cause of cancerrelated death worldwide Early detection of lung cancer can help reduce the death rate therefore the identification of potential biomarkers is crucial
mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis
RNA abundance is controlled by rates of synthesis and degradation Although misregulation of RNA turnover is linked to neurodevelopmental disorders how it contributes to cortical development is largely unknown
Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa
The RNA degradosome is a bacterial multiprotein complex mediating mRNA processing and degradation In Pseudomonadota this complex assembles on the Cterminal domain CTD of RNase E through short linear motifs SLiMs that determine
A novel oncolytic vaccinia virus with multiple gene modifications involved in viral replication and maturation increases safety for intravenous administration while maintaining proliferative
To generate a novel oncolytic vaccinia virus with improved safety and productivity the genome of smallpox vaccine strain LCm was modified by a bacterial artificial chromosome system By using LCm
Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE
Bacteria can quickly adapt to sublethal concentrations of antibiotics Several stress and DNA repair genes contribute to this adaptation process However the pathways leading to adaptation by acquisition of de novo mutations remain poorly understood
Two transmembrane transcriptional regulators coordinate to activate chitin-induced natural transformation in Vibrio cholera
Transcriptional regulators are a broad class of proteins that alter gene expression in response to environmental stimuli Transmembrane transcriptional regulators TTRs are a subset of transcriptional regulators in bacteria that can directly regulate gene expression while remaining anchored in the membrane
Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors
Hepatitis B virus HBV ribonuclease H RNaseH inhibitors are a potent class of antivirals that prevent degradation of the viral pregenomic RNA during reverse transcription and block formation of mature HBV DNAs
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
This study aimed to evaluate clinical control in chronic obstructive pulmonary disease COPD the consequences in terms of treatment decisions and their potentially associated factors during followup of patients in reallife clinical practice
