Research Insights
The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.
Screening for variable drug responses using human iPSC cohorts
We have developed a laboratorybased drug screening platform that uses a cohort of human induced pluripotent stem cell hiPSC lines derived from different donors to predict variable drug responses of potential clinical relevance
Disentangling the mutational effects on protein stability and interaction of human MLH1
Missense mutations can have diverse effects on proteins depending on their location within the protein and the specific amino acid substitution Mutations in the DNA mismatch repair gene MLH are associated with Lynch syndrome
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
MicroRNAs miRNAs are small RNAs that silence messenger RNAs mRNAs by binding to partially complementary sequences They play a crucial role in cell type specification during development Computational models
Design, synthesis, and in vitro evaluation of a carbamazepine derivative with antitumor potential in a model of Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia ALL is a significant concern in both pediatric and adult demographics Despite approved cancer therapies based on small molecules a mere five apply to all types of leukemia
Coordination of cell envelope biology by Escherichia coli MarA protein potentiates intrinsic antibiotic resistance
The multiple antibiotic resistance activator MarA protein is a transcription factor implicated in control of intrinsic antibiotic resistance in enteric bacterial pathogens In this work we screened the Escherichia coli genome
Significant roles in RNA-binding for the amino-terminal regions of Drosophila Pumilio and Nanos
The Drosophila Pumilio Pum and Nanos Nos RNAbinding proteins govern abdominal segmentation in the early embryo as well as a variety of other events during development They bind together to a compound Nanos Response Element NRE
Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer’s disease
Genomewide association studies GWAS performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimers disease AD
Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer’s disease
Genomewide association studies GWAS performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimers disease AD
Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes
Genetic variation can modulate response to treatment GT or environmental stimuli GE both of which can be highly consequential in biomedicine An effective approach to identifying GT signals and gaining insight into molecular
Parental germline mosaicism in genome-wide phased de novo variants: Recurrence risk assessment and implications for precision genetic counselling
De novo mutations DNMs have a significant impact on human health notably through their contribution to developmental disorders DNMs occur in both paternal and maternal germlines via diverse mechanisms
